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Low serum uric acid levels are associated with the nonmotor symptoms and brain gray matter volume in Parkinsons disease

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Angiogenesis support (new blood-vessel signaling) via VEGFR2 Akt eNOS (nitric oxide) pathways

Figure 1 Given that the E4 allele is associated with both an increased reliance on alternative fuels, such as FAs, and more severe cerebrovascular dysfunction with age (Yassine and Finch, 2020